Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion ME, Bullock B, Li M, Lyons CE, Adams RJ, Gama L, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 infection. J Infect Dis. 2015. PMC4601916.
Metcalf Pate KA, Lyons CE, Dorsey JL, Queen SE, Adams RJ, Morrell CN, Mankowski JL. TGFβ mediated downregulation of thrombopoietin is associated with platelet decline in asymptomatic SIV infection. JAIDS. 2014. PMC3999250.
Metcalf Pate KA, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. Platelet activation and platelet-monocyte aggregate formation contribute to platelet decline during acute SIV infection in pigtailed macaques. J Infect Dis. 2013. PMCID23852120
Metcalf Pate KA, Mankowski JL. HIV and SIV associated thrombocytopenia: an expanding role for platelets in the pathogenesis
of HIV. Drug Discov Today Dis Mech. 2011. PMCID22577463. Invited Review.
Metcalf Pate KA, Lyons CE, Dorsey JL, Queen SE, Adams RJ, Morrell CN, Mankowski JL. TGFβ mediated downregulation of thrombopoietin is associated with platelet decline in asymptomatic SIV infection. JAIDS. 2014. PMC3999250.
Metcalf Pate KA, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. Platelet activation and platelet-monocyte aggregate formation contribute to platelet decline during acute SIV infection in pigtailed macaques. J Infect Dis. 2013. PMCID23852120
Metcalf Pate KA, Mankowski JL. HIV and SIV associated thrombocytopenia: an expanding role for platelets in the pathogenesis
of HIV. Drug Discov Today Dis Mech. 2011. PMCID22577463. Invited Review.
Collaboratory Research
Kelly KM, Beck SE, Metcalf Pate KA, Queen SE, Dorsey JL, Adams RJ, Avery L, Hubbard W, Tarwater PM, Mankwoski JL. Neuroprotective maraviroc monotherapy in SIV-infected macaques: reduced replicating and latent SIV in the brain. AIDS. In
press.
Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL. CCR5 Inhibition Prevents Cardiac Dysfunction in the SIV/Macaque Model of HIV. J Am Heart Assoc. 2014; 3(2):e000874. PMCID 24695652.
Dorsey JL, Mangus LM, Oakley JD, Beck, SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams FJ, Marfurt CF, Mankowski JL. Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage. AJP. 2014; 184(6): 1652-9. PMCID 24828391.
Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK. Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry. 2015; 5:e567. doi: 10.1038/tp.2015.61. PMID: 25989141.
Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015; epub ahead of print. PMCID 25818747
press.
Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL. CCR5 Inhibition Prevents Cardiac Dysfunction in the SIV/Macaque Model of HIV. J Am Heart Assoc. 2014; 3(2):e000874. PMCID 24695652.
Dorsey JL, Mangus LM, Oakley JD, Beck, SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams FJ, Marfurt CF, Mankowski JL. Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage. AJP. 2014; 184(6): 1652-9. PMCID 24828391.
Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK. Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry. 2015; 5:e567. doi: 10.1038/tp.2015.61. PMID: 25989141.
Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015; epub ahead of print. PMCID 25818747
Clinical Manuscripts
Baxter VK, Shaw GC, Sotuyo NP, Carlson CS, Olson EJ, Zink MC, Mankowski JL, Adams RJ, Hutchinson EK, Metcalf Pate KA. Serum Albumin and Body Weight as Biomarkers for the Antemortem Identification of Bone and Gastrointestinal Disease in the Common Marmoset. PLoS One. In press.
Rice KA, Brzezenski LK, Metcalf Pate KA, Perkins C, Henderson KS, Watson J. Evaluation of Diagnostic Methods for Myocoptes musculinus According to Age and Treatment Status of Mice (Mus musculus). J Am Assoc Lab Anim Sci. 2013; 52(6):1-9.
Rice KA, Chen ES, Metcalf Pate KA, Hutchinson EK, Adams RJ. Diagnosis of amyloidosis and differentiation from chronic, idiopathic
enterocolitis in rhesus (Macaca mulatta) and pigtailed macaques (Macaca nemestrina). Comp Med. 2013; 63(3): 262-271. PMCID23759529
Metcalf Pate KA, Rice KA, Wrighten R, Watson J. In Search of the Elusive Myocoptes Musculinus Fur Mite: Evaluation of the Effect of Sampling Strategy on the Detection of Fur Mites within a Naturally Infested Colony of Mice (Mus musculus). J Am Assoc Lab Anim Sci.
2011; 50(3): 337-343. PMCID21640028
Cooper CS, Metcalf Pate KA, Barat CE, Cook JA, Scorpio DG. Comparison of Side Effects between Buprenorphine and Meloxicam Used Postoperatively in Dutch Belted Rabbits (Oryctolagus cuniculus). J Am Assoc Lab Anim Sci. 2009; 48(2): 279-285. PMCID19476717
Olson EJ, Shaw GC, Hutchinson EK, Schultz-Darken N, Bolton ID, Parker JB, Morrison JM, Baxter VK, Pate KA, Mankowski JL, Carlson CS. Bone Disease in the Common Marmoset: Radiographic and Histological Findings. Vet Pathol. 2015; epub ahead of print. PMID: 26077785.
Rice KA, Brzezenski LK, Metcalf Pate KA, Perkins C, Henderson KS, Watson J. Evaluation of Diagnostic Methods for Myocoptes musculinus According to Age and Treatment Status of Mice (Mus musculus). J Am Assoc Lab Anim Sci. 2013; 52(6):1-9.
Rice KA, Chen ES, Metcalf Pate KA, Hutchinson EK, Adams RJ. Diagnosis of amyloidosis and differentiation from chronic, idiopathic
enterocolitis in rhesus (Macaca mulatta) and pigtailed macaques (Macaca nemestrina). Comp Med. 2013; 63(3): 262-271. PMCID23759529
Metcalf Pate KA, Rice KA, Wrighten R, Watson J. In Search of the Elusive Myocoptes Musculinus Fur Mite: Evaluation of the Effect of Sampling Strategy on the Detection of Fur Mites within a Naturally Infested Colony of Mice (Mus musculus). J Am Assoc Lab Anim Sci.
2011; 50(3): 337-343. PMCID21640028
Cooper CS, Metcalf Pate KA, Barat CE, Cook JA, Scorpio DG. Comparison of Side Effects between Buprenorphine and Meloxicam Used Postoperatively in Dutch Belted Rabbits (Oryctolagus cuniculus). J Am Assoc Lab Anim Sci. 2009; 48(2): 279-285. PMCID19476717
Olson EJ, Shaw GC, Hutchinson EK, Schultz-Darken N, Bolton ID, Parker JB, Morrison JM, Baxter VK, Pate KA, Mankowski JL, Carlson CS. Bone Disease in the Common Marmoset: Radiographic and Histological Findings. Vet Pathol. 2015; epub ahead of print. PMID: 26077785.
Oral Presentations (with published abstract)
Metcalf Pate KA*, Kelly K, Zink MC, Mankowski JL. October 30, 2010. Case 62520: Male pigtail macaque with SIV-associated pulmonary arteriopathy. American College of Veterinary Pathologists (ACVP) Primate Pathology Workshop, Baltimore, MD.
Baxter VK*, Hutchinson EK, Shaw GC, Metcalf Pate KA. November 3-8, 2012. Clinical and biochemical characterization of Bone and Gut Syndrome in the common marmoset (Callithrix jacchus). American Association for Laboratory Animal Science (AALAS), Minneapolis, MN.
Metcalf Pate KA*, Freeman ZT, Shirk E, Rice KA, Adams RJ, Mankowski JL, Hutchinson EK. November 6, 2012. Platelet activation in the context of stress in self-injurious rhesus macaques. American Association for Laboratory Animal Science (AALAS), Minneapolis, MN.
Metcalf Pate KA*, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. March 10, 2013. Platelet activation and platelet-monocyte aggregate formation contribute to platelet decline during acute SIV infection in pigtailed macaques. Gordon Research Seminar on Cell Biology of Megakaryocytes and Platelets, Galveston, TX.
Metcalf Pate KA*, Morrell CN, Mankowski JL, Witwer KW. April 18, 2013. Platelet activation and microparticle formation in acute SIV infection. International Society for Extracellular Vesicles, Boston, MA.
Metcalf Pate KA*, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. October 27-31, 2013. Platelet Activation and Platelet-Monocyte Aggregate Formation Contribute to Platelet Decline during Acute Infection in the SIV-Infected Pigtailed Macaque Model of HIV Infection. American Association for Laboratory Animal Science (AALAS), Baltimore, MD.
Izzi J*, Hutchinson EK, Metcalf Pate KA. 2014. Cobalamin (Vitamin B12) Deficiency in Rhesus and Pig-tailed Macaques with Chronic Diarrhea. Association for Primate Veterinarians, San Antonio, TX. (winner of trainee travel grant award for J Izzi)
Metcalf Pate KA*. 2014. The Laboratory Animal Professional's Guide to the World Of Vaccine Immunology: What Do I Need to Know About Innate Immunity? American Association for Laboratory Animal Science (AALAS), San Antonio, TX.
Lyons CE, Schneider H, Engle L, Najarro KM, Queen SE, Morrell CN, Mankowski JL, Metcalf Pate KA*. June 22nd, 2015. Platelet activation and platelet-endothelial interactions in the SIV-infected pigtail macaque model of HIV-associated CNS disease. International Society for Thrombosis and Haemostasis (ISTH), Toronto, ON, Canada.
Metcalf Pate KA*, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion ME, Bullock B, Li M, Lyons CE, Adams RJ, Gama L, Zink MC, Clements JE, Mankowski JL, Blankson JN. July 20th, 2015. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. International AIDS Society (IAS), Vancouver, BC, Canada.
Metcalf Pate KA*. Invited talk for October 17th, 2015. Platelet function testing in nonhuman primates. American College of Veterinary Pathologists (ACVP) Clinical Pathology Workshop, Minneapolis, MN.
Vermillion MS*, Lyons CE, Najarro KM, Freeman Z, Adams RJ, Metcalf Pate KA. Accepted for November 1-5, 2015. Platelets are activated in response to serial sedation and blood collection in pigtailed macaques. American Association for Laboratory Animal Science (AALAS), Phoenix, AZ.
Baxter VK*, Hutchinson EK, Shaw GC, Metcalf Pate KA. November 3-8, 2012. Clinical and biochemical characterization of Bone and Gut Syndrome in the common marmoset (Callithrix jacchus). American Association for Laboratory Animal Science (AALAS), Minneapolis, MN.
Metcalf Pate KA*, Freeman ZT, Shirk E, Rice KA, Adams RJ, Mankowski JL, Hutchinson EK. November 6, 2012. Platelet activation in the context of stress in self-injurious rhesus macaques. American Association for Laboratory Animal Science (AALAS), Minneapolis, MN.
Metcalf Pate KA*, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. March 10, 2013. Platelet activation and platelet-monocyte aggregate formation contribute to platelet decline during acute SIV infection in pigtailed macaques. Gordon Research Seminar on Cell Biology of Megakaryocytes and Platelets, Galveston, TX.
Metcalf Pate KA*, Morrell CN, Mankowski JL, Witwer KW. April 18, 2013. Platelet activation and microparticle formation in acute SIV infection. International Society for Extracellular Vesicles, Boston, MA.
Metcalf Pate KA*, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. October 27-31, 2013. Platelet Activation and Platelet-Monocyte Aggregate Formation Contribute to Platelet Decline during Acute Infection in the SIV-Infected Pigtailed Macaque Model of HIV Infection. American Association for Laboratory Animal Science (AALAS), Baltimore, MD.
Izzi J*, Hutchinson EK, Metcalf Pate KA. 2014. Cobalamin (Vitamin B12) Deficiency in Rhesus and Pig-tailed Macaques with Chronic Diarrhea. Association for Primate Veterinarians, San Antonio, TX. (winner of trainee travel grant award for J Izzi)
Metcalf Pate KA*. 2014. The Laboratory Animal Professional's Guide to the World Of Vaccine Immunology: What Do I Need to Know About Innate Immunity? American Association for Laboratory Animal Science (AALAS), San Antonio, TX.
Lyons CE, Schneider H, Engle L, Najarro KM, Queen SE, Morrell CN, Mankowski JL, Metcalf Pate KA*. June 22nd, 2015. Platelet activation and platelet-endothelial interactions in the SIV-infected pigtail macaque model of HIV-associated CNS disease. International Society for Thrombosis and Haemostasis (ISTH), Toronto, ON, Canada.
Metcalf Pate KA*, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion ME, Bullock B, Li M, Lyons CE, Adams RJ, Gama L, Zink MC, Clements JE, Mankowski JL, Blankson JN. July 20th, 2015. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. International AIDS Society (IAS), Vancouver, BC, Canada.
Metcalf Pate KA*. Invited talk for October 17th, 2015. Platelet function testing in nonhuman primates. American College of Veterinary Pathologists (ACVP) Clinical Pathology Workshop, Minneapolis, MN.
Vermillion MS*, Lyons CE, Najarro KM, Freeman Z, Adams RJ, Metcalf Pate KA. Accepted for November 1-5, 2015. Platelets are activated in response to serial sedation and blood collection in pigtailed macaques. American Association for Laboratory Animal Science (AALAS), Phoenix, AZ.
Posters (with published abstract)
Metcalf KA*, Adissu HA, Lelièvre SL. December 2005. The effect of fatty acids and estrogen on tissue polarity of mammary epithelial cells. American College of Veterinary Pathologists (ACVP), Boston, MA.
Metcalf Pate KA*, Morrell CN, Mankowski JL. November 8-12, 2009. Characterization of platelet decline during acute SIV infection in the pig-tailed macaque (Macaca nemestrina). American Association for Laboratory Animal Science (AALAS), Denver, CO.
Metcalf Pate KA*, Morrell CN, Mankowski JL. March 5-8, 2012. The role of platelets during acute infection in SIV infection. Conference on Retroviruses and Opportunistic Infections, Seattle, WA.
Metcalf Pate KA*, Lyons CE, Dorsey JL, Morrell CN, Mankowski JL. June 7-11, 2012. The impact of SIV infection on platelet activation and production. Platelets 2012 International Symposium, Beverly, MA.
Baxter VK*, Sotuyo NP, Shaw GC, Hutchinson EK, Metcalf Pate KA. October 27-31, 2013. Progressive body weight trends predict development of Bone and Gastrointestinal Syndrome in the common marmoset (Callithrix jacchus). American Association for Laboratory Animal Science (AALAS), Baltimore, MD.
Lyons CE*, Dorsey JL, Metcalf Pate KA, Mankowski JL. October 27-31, 2013. Novel method for quantification of cells in bone marrow tissue sections. American Association for Laboratory Animal Science (AALAS), Baltimore, MD.
Lyons CE, Schneider HH, Najarro KM, Adams RJ, Engle EL, Queen SE, Morrell CN, Mankowski JL, Metcalf Pate KA*. July 27 – August 1, 2014. Platelet-endothelial interactions in SIV-associated CNS disease. Gordon Research Conference on Hemostasis, Waterville Valley, NH.
Vermillion M*, Lyons CE, Freeman Z, Witwer KK, Adams RJ, Metcalf Pate KA. 2014. Effect of Changes to Social Environment on Platelet Activation and Function in Pigtailed Macaques. American Association for Laboratory Animal Science (AALAS), San Antonio, TX.
Lyons CE, Schneider H, Engle L, Najarro KM, Queen SE, Morrell CN, Mankowski JL, Metcalf Pate KA*. February 23 – 26, 2015. Platelet-endothelial interactions in SIV-associated CNS disease. Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, WA.
Brockhurst JK*, Najarro KM, Cryer CG, Su YP, Boger R, Metcalf Pate KA. Accepted for July 30th – August 2nd, 2015. Does platelet-monocyte aggregate formation contribute to platelet decline in acute cytomegalovirus infection? Merial Veterinary Scholars Symposium, Davis, CA.
Metcalf Pate KA*, Morrell CN, Mankowski JL. November 8-12, 2009. Characterization of platelet decline during acute SIV infection in the pig-tailed macaque (Macaca nemestrina). American Association for Laboratory Animal Science (AALAS), Denver, CO.
Metcalf Pate KA*, Morrell CN, Mankowski JL. March 5-8, 2012. The role of platelets during acute infection in SIV infection. Conference on Retroviruses and Opportunistic Infections, Seattle, WA.
Metcalf Pate KA*, Lyons CE, Dorsey JL, Morrell CN, Mankowski JL. June 7-11, 2012. The impact of SIV infection on platelet activation and production. Platelets 2012 International Symposium, Beverly, MA.
Baxter VK*, Sotuyo NP, Shaw GC, Hutchinson EK, Metcalf Pate KA. October 27-31, 2013. Progressive body weight trends predict development of Bone and Gastrointestinal Syndrome in the common marmoset (Callithrix jacchus). American Association for Laboratory Animal Science (AALAS), Baltimore, MD.
Lyons CE*, Dorsey JL, Metcalf Pate KA, Mankowski JL. October 27-31, 2013. Novel method for quantification of cells in bone marrow tissue sections. American Association for Laboratory Animal Science (AALAS), Baltimore, MD.
Lyons CE, Schneider HH, Najarro KM, Adams RJ, Engle EL, Queen SE, Morrell CN, Mankowski JL, Metcalf Pate KA*. July 27 – August 1, 2014. Platelet-endothelial interactions in SIV-associated CNS disease. Gordon Research Conference on Hemostasis, Waterville Valley, NH.
Vermillion M*, Lyons CE, Freeman Z, Witwer KK, Adams RJ, Metcalf Pate KA. 2014. Effect of Changes to Social Environment on Platelet Activation and Function in Pigtailed Macaques. American Association for Laboratory Animal Science (AALAS), San Antonio, TX.
Lyons CE, Schneider H, Engle L, Najarro KM, Queen SE, Morrell CN, Mankowski JL, Metcalf Pate KA*. February 23 – 26, 2015. Platelet-endothelial interactions in SIV-associated CNS disease. Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, WA.
Brockhurst JK*, Najarro KM, Cryer CG, Su YP, Boger R, Metcalf Pate KA. Accepted for July 30th – August 2nd, 2015. Does platelet-monocyte aggregate formation contribute to platelet decline in acute cytomegalovirus infection? Merial Veterinary Scholars Symposium, Davis, CA.